{"id":18,"date":"2026-07-01T08:13:11","date_gmt":"2026-07-01T08:13:11","guid":{"rendered":"https:\/\/cellbiology-dev.i-med.ac.at\/?page_id=18"},"modified":"2026-07-20T09:04:06","modified_gmt":"2026-07-20T09:04:06","slug":"the-vietor-laboratory","status":"publish","type":"page","link":"https:\/\/cellbiology-dev.i-med.ac.at\/index.php\/the-vietor-laboratory\/","title":{"rendered":"The Vietor Laboratory"},"content":{"rendered":"
\n
\n
\n
\n\n
\"\"<\/picture><\/div>
<\/div><\/div>
\"\"<\/picture><\/div>
<\/div><\/div>
\"\"<\/picture><\/div>
<\/div><\/div>
\"\"<\/picture><\/div>
<\/div><\/div>
\"\"<\/picture><\/div>
<\/div><\/div><\/div>
\n <\/svg>
Startseite_Gebaude-2-scaled<\/div>
<\/div><\/div><\/div>
Labor-scaled<\/div>
<\/div><\/div><\/div>
entry-pics1<\/div>
<\/div><\/div><\/div>
entry-pics2<\/div>
<\/div><\/div><\/div>
cropped-Bild_home_Zelle-e1633955489502-1<\/div>
<\/div><\/div><\/div> <\/div>\n\n <\/div>\n <\/div>\n <\/div>\n
\"previous<\/div><\/div>
\"next<\/div><\/div><\/div><\/div><\/ss3-loader><\/div><\/div>
<\/div><\/div><\/ss3-force-full-width><\/div>\n\n\n

The Vietor Laboratory: Regulatory Mechanisms of Cell Differentiation<\/h1>\n\n\n\n

Our group is interested in the roles of the TPA-induced sequence-7 (TIS7, also known as IFRD1) protein and its orthologue SKMc15 (IFRD2). We have shown that they are involved in the regulation of the differentiation of neurons, enterocytes, myocytes and adipocytes and that TIS7 is a transcriptional co-regulator (Lammirato et al., BMC Biol, 2016). We have generated TIS7 and SKMc15 double knockout (dKO) mice and used them to identify a regulatory role for TIS7 in adipocyte differentiation and in resistance to high-fat diet (Vietor et al. eLife, 2023). As dKO mice are substantially leaner, we propose that TIS7 and SKMc15 are involved in physiological adipocyte differentiation. However, our mouse model does not enable us to distinguish between a systemic and a tissue-specific role of the two genes. We are thus generating constitutive knockout mouse models that specifically lack the expression of these genes in either the small intestine or adipocyte tissues. We are also establishing mouse organoid technology to limit the use of experimental animals and to permit us to study the role of the two genes more closely.<\/p>\n\n\n\n

\"\"
Adipocyte differentiation is regulated by TIS7 and SKMc15.<\/strong> Oil red O-staining of MEF cells isolated from wild-type (WT), TIS7, SKMc15 single knockout and TIS7 SKMc15 double knockout mice after 8 days of the adipocyte differentiation protocol<\/figcaption><\/figure>\n\n\n\n

Publications<\/h2>\n\n\n\n